Role of TRPV1 in thermoregulation

      Transient receptor potential vanilloid-1 (TRPV1) is the founding member of larger family of TRP ion channels. As a molecular integrator of multiple physical and chemical stimuli, TRPV1 plays important role in numerous biological processes including thermoregulation. In fact, involvement of TRPV1 in thermoregulation and thermosensation is so prominent that it is hindering a development of safe drugs targeting other functions of TRPV1 such as emergence and the maintenance of pain. This presentation will review our current understanding of thermoregulatory function of TRPV1 based on mechanistic studies conducted by using pharmacological and genetic tools.
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