Highlights
- •Autonomic regulation in migraine patients with/without hypertension was compared with healthy subjects matched by age/sex.
- •Migrainers with hypertension have reduced arterial baroreflex but parameters of cardiac autonomic regulation were unchanged.
- •Increased vasomotor reactivity in migrainers with or without hypertension was associated with the family history of cardiovascular diseases.
Abstract
Recent studies indicate that migraine is associated with increased risk of cardiovascular
diseases. However, links between autonomic cardiovascular regulation, arterial hypertension
(AH) and migraine are still little explored. In this study, we evaluated autonomic
regulation in migraine patients with and without hypertension. We studied 104 patients
with migraine, aged 34 ± 10 y, including 28 with and 76 without hypertension (M + AH and M − AH groups, respectively). The control group consisted of 88 healthy volunteers matched
by age and sex. The autonomic regulation of circulation was examined with the tilt-table
test, deep-breathing and Valsalva Maneuver, handgrip test, cold-stress induced vasoconstriction,
arterial baroreflex, and blood pressure variability measurements. We found that migraine
patients with concomitant hypertension demonstrated reduced arterial baroreflex, whereas
other parameters of cardiac autonomic regulation were unchanged. In contrast, most
indicators of vasomotor reactivity (blood pressure response to the hand-grip, Valsalva
maneuver and cold vasoconstriction) were enhanced in migraine patients with no significant
differences between migraine patients with and without hypertension. Patients from
both M + AH and M − AH groups more commonly had a family history of cardiovascular disorders. Our data
revealed increased vasomotor reactivity in migraine patients, with or without concomitant
hypertension. This was associated with the family history of cardiovascular diseases.
Keywords
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Article info
Publication history
Published online: January 24, 2017
Accepted:
January 23,
2017
Received in revised form:
January 10,
2017
Received:
May 27,
2016
Identification
Copyright
© 2017 Elsevier B.V. All rights reserved.
