Glia and central cardiorespiratory pathology


      • Cardiorespiratory pathology includes hypertension and myocardial infarction.
      • Microglia and astrocytes provide immunity, injury repair, and metabolic support to CNS neurons.
      • Glial cells play a role in the development of cardiorespiratory pathology.


      Respiration and blood pressure are primarily controlled by somatic and autonomic motor neurones, respectively. Central cardiorespiratory control is critical in moment-to-moment survival, but it also has a role in the development and maintenance of chronic pathological conditions such as hypertension. The glial cells of the brain are non-neuronal cells with metabolic, immune, and developmental functions. Recent evidence shows that glia play an active role in supporting and regulating the neuronal circuitry which drives the cardiorespiratory system. Here we will review the activities of two key types of glial cell, microglia and astrocytes, in assisting normal central cardiorespiratory control and in pathology.


      2K1C (two-kidney one-clip), ACE (angiotensin converting enzyme), ADP (adenosine diphosphate), AIH (acute intermittent hypoxia), AngII (angiotensin II), ATP (adenosine triphosphate), CIH (chronic intermittent hypoxia), CNS (central nervous system), CX3CR1 (fractalkine receptor), ICV (intracerebroventricular), IFNγ (interferon gamma), IL-1β (interleukin-1 beta), IL-4, IL-6, IL-10, IL-13 (interleukin 4, 6, 10, 13), JAM-1 (junctional adhesion molecule 1), LPS (lipopolysaccharide), mGluR (metabotropic glutamate receptor), NTS (nucleus tractus solitarius), pLTF (phrenic long-term facilitation), PVN (paraventricular nucleus of the hypothalamus), RSNA (renal sympathetic nerve activity), RVLM (rostral ventrolateral medulla), SHR (spontaneously hypertensive rats), SHR-SP (stroke-prone spontaneously hypertensive rats), TLR4 (toll-like receptor 4), TNFα (tumour necrosis factor alpha), UDP (uridine diphosphate), WKY (Wistar-Kyoto rats)


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