Highlights
- •Association of striatal dopamine depletion with autonomic symptoms was assessed in untreated PD.
- •Autonomic symptoms were evaluated using the SCOPA-AUT.
- •Lower DAT activity in the putamen but not in the caudate was related to urinary symptoms.
- •Striatal DAT activities were not associated with other autonomic symptoms.
Abstract
While the involvement of the central and peripheral autonomic networks is thought
to play an integral role in the development of autonomic symptoms in Parkinson's disease
(PD), there is little evidence for an association between autonomic symptoms and striatal
dopaminergic depletion. We compared dopamine transporter activity in striatal subregions
with various autonomic symptoms covered by the SCOPA-AUT domains including gastrointestinal,
urinary, cardiovascular, thermoregulatory, pupillomotor, and sexual symptoms in 418
untreated patients with PD. We found evidence for a dopaminergic association with
only urinary symptoms. Moreover, dopaminergic denervation in the putamen but not in
the caudate may underlie these symptoms.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Autonomic Neuroscience: Basic and ClinicalAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Neuropathology of autonomic dysfunction in synucleinopathies.Mov. Disord. 2018; 33: 349-358
- Disrupted hypothalamic functional connectivity in patients with PD and autonomic dysfunction.Neurology. 2018; 90: e2051-e2058
- Assessing autonomic symptoms of Parkinson's disease with the SCOPA-AUT: a new perspective from Rasch analysis.Eur. J. Neurol. 2010; 17: 273-279
- Nonmotor effects of conventional and transdermal dopaminergic therapies in Parkinson's disease.Int. Rev. Neurobiol. 2017; 134: 989-1018
- Presynaptic striatal dopaminergic depletion predicts the later development of freezing of gait in de novo Parkinson's disease: an analysis of the PPMI cohort.Parkinsonism Relat. Disord. 2018; 51: 49-54
- Brain activation during detrusor overactivity in patients with Parkinson's disease: a positron emission tomography study.J. Urol. 2006; 175: 994-998
- Human brain region response to distention or cold stimulation of the bladder: a positron emission tomography study.J. Urol. 2002; 168: 2035-2039
- Autonomic dysfunction in Parkinson's disease: a prospective cohort study.Mov. Disord. 2018; 33: 391-397
- Autonomic and sensory symptoms and signs in incident, untreated Parkinson's disease: frequent but mild.Mov. Disord. 2011; 26: 65-72
- Lower urinary tract dysfunction in the neurological patient: clinical assessment and management.Lancet Neurol. 2015; 14: 720-732
- SPECT imaging of the dopamine transporter with [(123)I]-beta-CIT reveals marked decline of nigrostriatal dopaminergic function in Parkinson's disease with urinary dysfunction.J. Neurol. Sci. 2001; 187: 55-59
- Relationship between nigrostriatal dopaminergic degeneration, urinary symptoms, and bladder control in Parkinson's disease.Eur. J. Neurol. 2005; 12: 842-850
Article info
Publication history
Published online: September 15, 2018
Accepted:
September 14,
2018
Received in revised form:
September 11,
2018
Received:
May 4,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
