Abstract
Electrical stimulation of the carotid baroreflex has been thoroughly investigated
for treating drug-resistant hypertension in humans. However, a previous study from
our laboratory, performed in conscious rats, has demonstrated that electrical stimulation
of the carotid sinus/nerve (CS) activated both the carotid baroreflex as well as the
carotid chemoreflex, resulting in hypotension. Additionally, we also demonstrated
that the carotid chemoreceptor deactivation potentiated this hypotensive response.
Therefore, to further investigate this carotid baroreflex/chemoreflex interaction,
besides the hemodynamic responses, we evaluated the respiratory responses to the electrical
stimulation of the CS in both intact (CONT) and carotid chemoreceptors deactivated
(CHEMO-X) conscious rats. CONT rats showed increased ventilation in response to electrical
stimulation of the CS as measured by the respiratory frequency (fR), tidal volume
(VT) and minute ventilation (VE), suggesting a carotid chemoreflex activation. The carotid chemoreceptor deactivation
abolished all respiratory responses to the electrical stimulation of the CS. Regarding
the hemodynamic responses, the electrical stimulation of the CS caused hypotensive
responses in CONT rats, which were potentiated by the carotid chemoreceptors deactivation.
Heart rate (HR) responses did not differ between groups. In conclusion, the present
study showed that the electrical stimulation of the CS, in conscious rats, activates
both the carotid baroreflex and the carotid chemoreflex driving an increase in ventilation
and a decrease in AP. These findings further contribute to our understanding of the
electrical stimulation of CS.
Keywords
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Article info
Publication history
Published online: December 03, 2018
Accepted:
December 1,
2018
Received in revised form:
November 30,
2018
Received:
August 17,
2018
Identification
Copyright
© 2018 Elsevier B.V. All rights reserved.
