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Early ovarian hormone deprivation increases cardiac contractility in old female rats—Role of physical training

Published:February 12, 2019DOI:https://doi.org/10.1016/j.autneu.2019.02.002

      Highlights

      • The early deprivation of ovarian hormones associated with the aging process promotes adverse cardiac remodeling.
      • The aerobic physical training is fundamental to attenuate these deleterious effects.
      • Physical training increase the maximal intraventricular pressure in response to induced flow increase.
      • However, reduce the left intraventricular pressure in response to dobutamina.
      • This effect is associated with the reduction of β-1 adrenergic receptors.

      Abstract

      Objectives

      We investigated the effects of early ovarian hormones deprivation on morphology and cardiac function and the effects of aerobic training on these parameters, in old rats.

      Methods

      Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24). Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography, cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression quantification.

      Results

      Echocardiography showed slight changes in morphology between OVX and SHAM groups. OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg). Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction in this response. While, β-adrenergic receptor expression was not different between the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased expression of these receptors.

      Conclusion

      Early ovarian hormones deprivation associated with aging, promotes discrete changes in cardiac morphology and increasing cardiac contractility. Aerobic training decreases β-adrenergic receptors expression, influencing the cardiac contractility.

      Keywords

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