Highlights
- •The early deprivation of ovarian hormones associated with the aging process promotes adverse cardiac remodeling.
- •The aerobic physical training is fundamental to attenuate these deleterious effects.
- •Physical training increase the maximal intraventricular pressure in response to induced flow increase.
- •However, reduce the left intraventricular pressure in response to dobutamina.
- •This effect is associated with the reduction of β-1 adrenergic receptors.
Abstract
Objectives
We investigated the effects of early ovarian hormones deprivation on morphology and
cardiac function and the effects of aerobic training on these parameters, in old rats.
Methods
Female Wistar rats (N = 48) were divided into two groups, at 10 weeks of life: early
ovarian hormones deprivation by ovariectomy (OVX; N = 24) and sham (SHAM; N = 24).
Between weeks 62 and 82, 12 animals of each group underwent aerobic training (OVX-T
and SHAM-T, N = 12). At the end of week 82, all were evaluated by echocardiography,
cardiac function (Langendorff technique) and cardiac β-adrenergic receptor expression
quantification.
Results
Echocardiography showed slight changes in morphology between OVX and SHAM groups.
OVX group (Δ = 101 ± 4.7 mmHg) showed higher values for maximal left intraventricular
pressure in response to dobutamine, when compared to SHAM group (Δ = 55 ± 11.8 mmHg).
Both OVX-T (Δ = 70 ± 4.0 mmHg) and SHAM-T (Δ = 22 ± 6.6 mmHg) groups showed a reduction
in this response. While, β-adrenergic receptor expression was not different between
the untrained groups, SHAM-T (0.23 ± 0.02 AU) and OVX-T (0.29 ± 0.01 AU), showed decreased
expression of these receptors.
Conclusion
Early ovarian hormones deprivation associated with aging, promotes discrete changes
in cardiac morphology and increasing cardiac contractility. Aerobic training decreases
β-adrenergic receptors expression, influencing the cardiac contractility.
Keywords
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Article info
Publication history
Published online: February 12, 2019
Accepted:
February 10,
2019
Received in revised form:
February 8,
2019
Received:
September 18,
2018
Identification
Copyright
© 2019 Elsevier B.V. All rights reserved.
