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Rapid Communication| Volume 218, P64-67, May 2019

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Takotsubo syndrome and left ventricular non-compaction cardiomyopathy: Casualty or causality?

Published:March 01, 2019DOI:https://doi.org/10.1016/j.autneu.2019.02.008
Takotsubo syndrome and left ventricular non-compaction cardiomyopathy: Casualty or causality?
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      Highlights

      • •
        Takotsubo syndrome (TS) is an acute form of neurocardiogenic stunning.
      • •
        Altered autonomic-limbic processing supports brain-heart axis in TS.
      • •
        Sympathetic activation with catecholamine release, causes myocardial toxicity and/or coronary microvascular dysfunction.
      • •
        Left ventricular non-compaction cardiomyopathy (LVNC) is a rare disease characterized by a subverted myocardial architecture.
      • •
        LVNC may predispose to TS because associated with coronary microvascular and autonomic dysfunction.

      Abstract

      Takotsubo syndrome (TS) is a condition of transient regional ventricular systolic dysfunction, usually presenting with acute chest pain and/or dyspnea, that is increasingly recognized especially in post-menopausal women following a psychological or physical stress. Initially considered as a benign condition with an isolated and self-limiting episode, it is now recognized that it is associated with a significant risk of in-hospital mortality and of recurrence. We herein describe a case of a 61-year-old female with left ventricular non-compaction cardiomyopathy (LVNC) who experienced a recurrence of TS, highlighting the potential pathophysiological role for LVNC in predisposing this syndrome and its recurrence. Moreover, we underscored possible therapeutic implications deriving from this case.

      Keywords

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      Article info

      Publication history

      Published online: March 01, 2019
      Accepted: February 27, 2019
      Received in revised form: February 27, 2019
      Received: November 26, 2018

      Identification

      DOI: https://doi.org/10.1016/j.autneu.2019.02.008

      Copyright

      © 2019 Elsevier B.V. All rights reserved.

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