Prevalence of hypermobile Ehlers-Danlos syndrome in postural orthostatic tachycardia syndrome

Published:January 10, 2020DOI:https://doi.org/10.1016/j.autneu.2020.102637

      Abstract

      Despite well-established clinical associations between Hypermobile Ehlers-Danlos syndrome (hEDS) and postural orthostatic tachycardia syndrome (POTS), the precise prevalence is unknown. We therefore evaluated for hEDS in 91 POTS participants using the 2017 hEDS diagnostic checklist, which has three major criteria: 1) generalized joint hypermobility (Beighton score), 2) systemic features, family history, and 3) absence of exclusion criteria. Overall, 28 out of 91 POTS participants (31%) met clinical criteria for hEDS. An additional 24% of participants had generalized joint hypermobility without meeting hEDS criteria. Identifying the prevalence of hEDS in POTS is important for understanding possible mechanisms connecting these two syndromes.

      Abbreviations:

      EDS (Ehlers-Danlos syndromes), hEDS (hypermobile Ehlers-Danlos syndrome), OI (orthostatic intolerance), POTS (postural orthostatic tachycardia syndrome)
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