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Selective abolition of Mayer waves in conscious endotoxemic rats

  • Author Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Claude Julien
    Correspondence
    Corresponding author.
    Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Affiliations
    EA 7426: Pathophysiology of Injury-Induced Immunosuppression (PI3), Université Claude Bernard - Lyon 1, Lyon, France
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  • Author Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Bruno Chapuis
    Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Affiliations
    Centre d'Imagerie Quantitative Lyon-Est, Lyon Multiscale Imaging Center, Université Claude Bernard - Lyon 1, Lyon, France
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  • Author Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Christian Barrès
    Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.
    Affiliations
    EA 7426: Pathophysiology of Injury-Induced Immunosuppression (PI3), Université Claude Bernard - Lyon 1, Lyon, France
    Search for articles by this author
  • Author Footnotes
    1 Postal address: 8 avenue Rockefeller, 69008 Lyon, France.

      Abstract

      The relation between vascular sympathetic tone and the amplitude of arterial pressure (AP) Mayer waves was examined by analyzing 60-min recordings of AP and renal sympathetic nerve activity (RSNA) obtained in conscious rats before and after lipopolysaccharide administration, which results in strong sympathoexcitation. Mayer waves completely disappeared together with accompanying oscillations of RSNA. Meanwhile, the gain of the sympathetic baroreceptor reflex was increased, thus suggesting that abolition of Mayer waves resulted from the previously reported reduction of vascular reactivity to α-adrenoceptor stimulation. In conclusion, the amplitude of Mayer waves cannot be used indiscriminately as an index of vascular sympathetic tone.

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      References

        • Barrès C.
        • de Souza Neto E.P.
        • Julien C.
        Effect of alpha-adrenoceptor blockade on the 0.4-Hz sympathetic rhythm in conscious rats.
        Clin. Exp. Pharmacol. Physiol. 2001; 28: 983-985
        • Berg R.M.
        • Plovsing R.R.
        • Greve A.M.
        • Christiansen C.B.
        • Toksvang L.N.
        • Holstein-Rathlou N.H.
        • Møller K.
        Spontaneous blood pressure oscillations in mechanically ventilated patients with sepsis.
        Blood Press. Monit. 2016; 21: 75-79
        • Bertram D.
        • Oréa V.
        • Chapuis B.
        • Barrès C.
        • Julien C.
        Differential responses of frequency components of renal sympathetic nerve activity to arterial pressure changes in conscious rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005; 289: R1074-R1082
        • Carrara M.
        • Bollen Pinto B.
        • Baselli G.
        • Bendjelid K.
        • Ferrario M.
        Baroreflex sensitivity and blood pressure variability can help in understanding the different response to therapy during acute phase of septic shock.
        Shock. 2018; 50: 78-86
        • Chapuis B.
        • Oréa V.
        • Barrès C.
        • Julien C.
        Very high frequency components of renal sympathetic nerve activity in conscious rats.
        Auton. Neurosci. 2010; 152: 55-59
        • Gallet C.
        • Julien C.
        The significance threshold for coherence when using the Welch’s periodogram method: effect of overlapping segments.
        Biomed. Signal Process. Control. 2011; 6: 405-409
        • Julien C.
        The enigma of Mayer waves: facts and models.
        Cardiovasc. Res. 2006; 70: 12-21
        • Julien C.
        An update on the enigma of Mayer waves.
        Cardiovasc. Res. 2020; https://doi.org/10.1093/cvr/cvz327
        • Julien C.
        • Oréa V.
        • Quintin L.
        • Piriou V.
        • Barrès C.
        Renal sympathetic nerve activity and vascular reactivity to phenylephrine after lipopolysaccharide administration in conscious rats.
        Physiol. Rep. 2017; 5: e13139
        • Kanbar R.
        • Oréa V.
        • Barrès C.
        • Julien C.
        Baroreflex control of renal sympathetic nerve activity during air-jet stress in rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 292: R362-R367
        • Kanbar R.
        • Oréa V.
        • Chapuis B.
        • Barrès C.
        • Julien C.
        A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats.
        Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 293: R1938-R1946
        • Lankadeva Y.R.
        • Booth L.C.
        • Kosaka J.
        • Evans R.G.
        • Quintin L.
        • Bellomo R.
        • May C.N.
        Clonidine restores pressor responsiveness to phenylephrine and angiotensin II in ovine sepsis.
        Crit. Care Med. 2015; 43: e221-e229
        • Liu C.
        • Zhang G.F.
        • Song S.W.
        • Cai G.J.
        • Liu W.H.
        • Miao C.Y.
        • Su D.F.
        Effects of ketanserin on endotoxic shock and baroreflex function in rodents.
        J. Infect. Dis. 2011; 204: 1605-1612
        • Miki K.
        • Yoshimoto M.
        Differential effects of behaviour on sympathetic outflow during sleep and exercise.
        Exp. Physiol. 2005; 90: 155-158
        • Mulder M.F.
        • van Lambalgen A.A.
        • van den Bos G.C.
        • Thijs L.G.
        The fall of cardiac output in endotoxemic rats cannot explain all changes in organ blood flow: a comparison between endotoxin and low venous return shock.
        Shock. 1996; 5: 135-140
        • Radaelli A.
        • Castiglioni P.
        • Cerrito M.G.
        • De Carlini C.
        • Soriano F.
        • Di Rienzo M.
        • Lavitrano M.L.
        • Paolini G.
        • Mancia G.
        Infusion of Escherichia coli lipopolysaccharide toxin in rats produces an early and severe impairment of baroreflex function in absence of blood pressure changes.
        Shock. 2013; 39: 204-209
        • Tohyama T.
        • Saku K.
        • Kawada T.
        • Kishi T.
        • Yoshida K.
        • Nishikawa T.
        • Mannoji H.
        • Kamada K.
        • Sunagawa K.
        • Tsutsui H.
        Impact of lipopolysaccharide-induced acute inflammation on baroreflex-controlled sympathetic arterial pressure regulation.
        PLoS One. 2018; 13: e0190830
        • van de Borne P.
        • Montano N.
        • Pagani M.
        • Oren R.
        • Somers V.K.
        Absence of low-frequency variability of sympathetic nerve activity in severe heart failure.
        Circulation. 1997; 95: 1449-1454