Abstract
Postural tachycardia syndrome (POTS) is a chronic form of orthostatic intolerance
associated with cognitive dysfunction. We hypothesized executive function and attention
is impaired in POTS during active standing. Eighty-seven POTS participants and 39
healthy controls of similar age, sex, and education level completed executive function
(Stroop word-color) and attention (CogState Identification) tests in supine and standing
postures in a cross-sectional study. POTS participants had lower executive function
(t-score: 48 ± 11 vs. 55 ± 10 control; p = 0.009) and worse attention (reaction speed:
2.78 ± 0.11 vs. 2.69 ± 0.06 control; p < 0.001) during standing. These data provide
new evidence that active standing impairs attention and executive functioning in POTS.
Keywords
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Article info
Publication history
Published online: June 05, 2020
Accepted:
May 23,
2020
Received in revised form:
April 20,
2020
Received:
January 6,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
