Highlights
- •More positive ANA antibodies in POTS patients with positive biopsy for Sjogren's
- •More small fiber neuropathy in in POTS patients with positive biopsy for Sjogren's
- •Certain antibodies and diagnostic tests are helpful in selecting POTS patients to biopsy.
Abstract
Purpose
POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation
of Sjogren's syndrome (SS). Predictive features of positive results are unknown.
Methods
161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic
testing results.
Results
Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA
antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated
with positive LSGB (p = .046).
Conclusion
A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS
patients for LSGB.
Keywords
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Article info
Publication history
Published online: June 16, 2020
Accepted:
June 8,
2020
Received in revised form:
May 19,
2020
Received:
February 9,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
