Highlights
- •More positive ANA antibodies in POTS patients with positive biopsy for Sjogren's
- •More small fiber neuropathy in in POTS patients with positive biopsy for Sjogren's
- •Certain antibodies and diagnostic tests are helpful in selecting POTS patients to biopsy.
Abstract
Purpose
POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation
of Sjogren's syndrome (SS). Predictive features of positive results are unknown.
Methods
161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic
testing results.
Results
Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA
antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated
with positive LSGB (p = .046).
Conclusion
A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS
patients for LSGB.
Keywords
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References
- Postural orthostatic tachycardia syndrome.Postgrad. Med. J. 2007; 83: 478-480
- The value of autonomic testing in postural tachycardia syndrome.Clin. Auton. Res. 2005; 15: 219-222
- Autoimmune markers and autoimmune disorders in patients with postural tachycardia syndrome (POTS).Lupus. 2015; 24: 1364-1369
- The pattern and diagnostic criteria of sensory neuronopathy: a case-control study.Brain. 2009; 132: 1723-1733
- A point-scoring system for the clinical diagnosis of Sjögren’s syndrome based on quantified SPECT imaging of salivary gland.PLoS One. 2016; 11: e0155666
- Postural orthostatic tachycardia syndrome: clinical presentation, aetiology and management.J. Intern. Med. 2019; 285: 352-366
- AB0437 complications of the minimally invasive biopsy of the minor salivary gland.Br. Med. J. 2016; : 1056-1057
- Structural and functional small fiber abnormalities in the neuropathic postural tachycardia syndrome.PLoS One. 2013; 8e84716
- Spectrum of autonomic nervous system impairment in Sjögren syndrome.Neurologist. 2017; 22: 127-130
- Diagnostic value of labial minor salivary gland biopsy for Sjögren’s syndrome: a systematic review.Autoimmun. Rev. 2013; 12: 416-420
- The REDCap consortium: building an international community of software platform partners.J. Biomed. Inform. 2019; 95: 103208
- Prospective evaluation of somatic and autonomic small fibers in selected autonomic neuropathies.Neurology. 2004; 62: 612-618
- The patient perspective: what postural orthostatic tachycardia syndrome patients want physicians to know.Auton. Neurosci. 2018; 215: 121-125
- Pathogenesis of hyperadrenergic orthostatic hypotension. Evidence of disordered venous innervation exclusively in the lower limbs.J. Clin. Invest. 1990; 86: 1582-1588
- Neurological disorders in primary Sjögren’s syndrome.Autoimmune Dis. 2012; : 645967
- Autoimmune postural orthostatic tachycardia syndrome.Ann. Clin. Transl. Neurol. 2018; 5: 486-492
Article Info
Publication History
Published online: June 16, 2020
Accepted:
June 8,
2020
Received in revised form:
May 19,
2020
Received:
February 9,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
