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Utility of salivary gland biopsy in diagnosing Sjogren's syndrome in a POTS patient population

  • Selena R. Pasadyn
    Affiliations
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America
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  • Christine B. Warren
    Affiliations
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America

    Department of Dermatology, Cleveland Clinic, United States of America
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  • Robert G. Wilson
    Correspondence
    Corresponding author at: Department of Neurology, Neuromuscular Center, Cleveland Clinic, 9500 Euclid Avenue, S31, Cleveland, OH 44195, United States of America.
    Affiliations
    Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, United States of America

    Department of Neurology, Neuromuscular Center, Cleveland Clinic, United States of America
    Search for articles by this author

      Highlights

      • More positive ANA antibodies in POTS patients with positive biopsy for Sjogren's
      • More small fiber neuropathy in in POTS patients with positive biopsy for Sjogren's
      • Certain antibodies and diagnostic tests are helpful in selecting POTS patients to biopsy.

      Abstract

      Purpose

      POTS patients undergo labial salivary gland biopsies (LSGB) for histologic confirmation of Sjogren's syndrome (SS). Predictive features of positive results are unknown.

      Methods

      161 POTS patients underwent LSGB. Their charts were reviewed for antibody and diagnostic testing results.

      Results

      Only 11% (17/161) of POTS patients were SS positive. There were more positive ANA antibodies in those with positive LSGB (65% v 28%, p = .0026). Positive skin nerve biopsy for small fiber neuropathy (SFN) was associated with positive LSGB (p = .046).

      Conclusion

      A positive ANA and skin biopsy for SFN are two helpful features in selecting POTS patients for LSGB.

      Keywords

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