Abstract
Damage to the insular cortex (IC) results in serious cardiovascular consequences and
evidence indicates that the characteristics are lateralized. However, a study comparing
the effects of focal experimental hemorrhage between IC sides was never performed.
We compared the cardiovascular, autonomic and cardiac changes produced by focal experimental
hemorrhage (ICH) into the left (L) or right (R) IC. Wistar rats were submitted to
microinjection of autologous blood (ICH) or saline (n = 6 each side/group) into the
R or L IC. Blood pressure (BP), heart rate (HR) and renal sympathetic activity (RSNA)
were recorded. Measurements of calcium transient and sarcoplasmic Ca2+ ATPase expression in cardiomyocytes were performed. ICH increased baseline HR (Δ:L-ICH
452 ± 13 vs saline 407 ± 11 bpm; R-ICH 450 ± 7 vs saline 406 ± 8 bpm, P < 0.05) without changing BP. HR was restored to baseline levels after i.v. atenolol.
Strikingly, ICH rats presented a reduced baseline RSNA (Δ:L-ICH 122 ± 4 vs saline
148 ± 11 spikes/s; R-ICH 112 ± 5 vs saline 148 ± 7 spikes/s, P < 0.05). After 24 h of ICH we observed a marked increase in cardiac ectopies and
this number was greater after ICH R-IC. Heart weight, calcium amplitude and SERCA
expression were reduced only in ICH R-IC. Focal stroke into IC can alter the cardiac
and renal autonomic control. Damage to the R-IC produces a greater number of arrhythmias
and changes in calcium dynamics in cardiac cells indicating that the cardiovascular
consequences are hemisphere-dependent. These findings confirm asymmetry for cardiac
autonomic control at the IC and help to understand the cardiac and renal implications
observed after specific side cortical damage.
Graphical abstract
Graphical Abstract
Keywords
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Article Info
Publication History
Published online: June 24, 2020
Accepted:
June 21,
2020
Received in revised form:
June 20,
2020
Received:
April 14,
2020
Identification
Copyright
© 2020 Elsevier B.V. All rights reserved.
