Autonomic function testing in long-COVID syndrome patients with orthostatic intolerance

  • Ahmed M. Eldokla
    Corresponding author at: 6620 Fly Road, Suite 302, East Syracuse, NY 13057, USA.
    Department of Neurology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA

    Department of Pathology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
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  • Sara T. Ali
    Department of Neurology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
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      The association between dysautonomia and long-COVID syndrome has gained considerable interest. This study retrospectively characterized the findings of autonomic reflex screen (ARS) in long-COVID patients presenting with orthostatic intolerance (OI). Fourteen patients were identified. All patients had normal cardiovagal function and 2 patients had abnormal sudomotor function. The head-up tilt table (HUTT) was significantly abnormal in 3 patients showing postural orthostatic tachycardia syndrome (POTS). CASS ranged from 0 to 2. The most common clinical scenario was symptoms of orthostatic intolerance without demonstrable HUTT orthostatic tachycardia or orthostatic hypotension (OH) (n = 8, 57 %). In our case series, most long-COVID patients presenting to our laboratory with OI had no significant HUTT abnormalities; only 3 patients met the criteria for POTS.


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