Abstract
The association between dysautonomia and long-COVID syndrome has gained considerable
interest. This study retrospectively characterized the findings of autonomic reflex
screen (ARS) in long-COVID patients presenting with orthostatic intolerance (OI).
Fourteen patients were identified. All patients had normal cardiovagal function and
2 patients had abnormal sudomotor function. The head-up tilt table (HUTT) was significantly
abnormal in 3 patients showing postural orthostatic tachycardia syndrome (POTS). CASS
ranged from 0 to 2. The most common clinical scenario was symptoms of orthostatic
intolerance without demonstrable HUTT orthostatic tachycardia or orthostatic hypotension
(OH) (n = 8, 57 %). In our case series, most long-COVID patients presenting to our laboratory
with OI had no significant HUTT abnormalities; only 3 patients met the criteria for
POTS.
Keywords
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References
- Autonomic uprising: the tilt table test in autonomic medicine.Clin. Auton. Res. 2019; 29 (Apr): 215-230https://doi.org/10.1007/s10286-019-00598-9
- Electrodiagnostic assessment of the autonomic nervous system: a consensus statement endorsed by the American Autonomic Society, American Academy of Neurology, and the International Federation of Clinical Neurophysiology.Clin. Neurophysiol. 2021; 132 (Feb): 666-682https://doi.org/10.1016/j.clinph.2020.11.024
- Autonomic dysfunction in 'long COVID': rationale, physiology and management strategies.Clin. Med. (Lond.). 2021; 21 (Jan): e63-e67https://doi.org/10.7861/clinmed.2020-0896
- Prevalence and patterns of symptoms of dysautonomia in patients with long-COVID syndrome: a cross-sectional study.Ann. Clin. Transl. Neurol. 2022; (Apr 8)https://doi.org/10.1002/acn3.51557
- Implications for neuromodulation therapy to control inflammation and related organ dysfunction in COVID-19.J. Cardiovasc. Transl. Res. 2020; 13 (Dec): 894-899https://doi.org/10.1007/s12265-020-10031-6
- The autonomic medical history.Clin. Auton. Res. 2017; 27 (Aug): 223-233https://doi.org/10.1007/s10286-017-0425-7
- (18)F-FDG brain PET hypometabolism in post-SARS-CoV-2 infection: substrate for persistent/delayed disorders?.Eur. J. Nucl. Med. Mol. Imaging. 2021; 48 (Feb): 592-595https://doi.org/10.1007/s00259-020-04973-x
- 6-Month consequences of COVID-19 in patients discharged from hospital: a cohort study.Lancet. 2021; 397: 220-232https://doi.org/10.1016/s0140-6736(20)32656-8
- Preparing for the long-haul: autonomic complications of COVID-19.Auton. Neurosci. 2021; 235 (Jul 3)102841https://doi.org/10.1016/j.autneu.2021.102841
- More than 50 long-term effects of COVID-19: a systematic review and meta-analysis. medRxiv.2021https://doi.org/10.1101/2021.01.27.21250617 (Jan 30)
- Composite autonomic scoring scale for laboratory quantification of generalized autonomic failure.Mayo Clin. Proc. 1993; 68 (Aug): 748-752https://doi.org/10.1016/s0025-6196(12)60631-4
- COVID-19 rapid guideline: managing the long-term effects of COVID-19.(Accessed 26 Nov 2021)
- Long-COVID postural tachycardia syndrome: an American Autonomic Society statement.Clin. Auton. Res. 2021; 31 (Jun): 365-368https://doi.org/10.1007/s10286-021-00798-2
- Neurological outcome and quality of life 3 months after COVID-19: a prospective observational cohort study.Eur. J. Neurol. 2021; 28 (Oct): 3348-3359https://doi.org/10.1111/ene.14803
- Idiopathic postural orthostatic tachycardia syndrome: an attenuated form of acute pandysautonomia?.Neurology. 1993; 43 (Jan): 132-137https://doi.org/10.1212/wnl.43.1_part_1.132
- Autonomic dysfunction following COVID-19 infection: an early experience.Clin. Auton. Res. 2021; 31 (Jun): 385-394https://doi.org/10.1007/s10286-021-00803-8
- Pediatric disorders of orthostatic intolerance.Pediatrics. 2018; 141 (Jan): 1https://doi.org/10.1542/peds.2017-1673
- Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness: consensus statement of the European Federation of Autonomic Societies (EFAS) endorsed by the American Autonomic Society (AAS) and the European Academy of Neurology (EAN).Clin. Auton. Res. 2021; 31 (Jun): 369-384https://doi.org/10.1007/s10286-020-00738-6
- The vagus nerve and the nicotinic anti-inflammatory pathway.Nat. Rev. Drug Discov. 2005; 4 (Aug): 673-684https://doi.org/10.1038/nrd1797
- Acute hyperhidrosis and postural tachycardia in a COVID-19 patient.Clin. Auton. Res. 2020; 30 (Dec): 571-573https://doi.org/10.1007/s10286-020-00733-x
Article Info
Publication History
Published online: June 01, 2022
Accepted:
May 30,
2022
Received in revised form:
May 8,
2022
Received:
January 17,
2022
Identification
Copyright
© 2022 Elsevier B.V. All rights reserved.