Abstract
Background
The importance of peripheral chemoreceptors for cardiorespiratory neural control is
known for decades. Pure oxygen inhalation deactivates chemoreceptors and increases
parasympathetic outflow. However, the relationship between autonomic nervous system
(ANS) activation and resulting respiratory as well as heart rate (HR) dynamics is
still not fully understood.
Methods
In young adults the impact of (1) 100 % pure oxygen inhalation (hyperoxic cardiac
chemoreflex sensitivity (CHRS) testing), (2) the cold face test (CFT) and (3) the
cold pressor test (CPT) on heart rate variability (HRV), hemodynamics and respiratory
rate was investigated in randomized order. Baseline ANS outflow was determined assessing
respiratory sinus arrhythmia via deep breathing, baroreflex sensitivity and HRV.
Results
Baseline ANS outflow was normal in all participants (23 ± 1 years, 7 females, 3 males).
Hyperoxic CHRS testing decreased HR (after 60 ± 3 vs before 63 ± 3 min−1, p = 0.004), while increasing total peripheral resistance (1053 ± 87 vs 988 ± 76 dyne*s + m2/cm5, p = 0.02) and mean arterial blood pressure (93 ± 4 vs 91 ± 4 mm Hg, p = 0.02). HRV
indicated increased parasympathetic outflow after hyperoxic CHRS testing accompanied
by a decrease in respiratory rate (15 ± 1vs 19 ± 1 min−1, p = 0.001). In contrast, neither CFT nor CPT altered the respiratory rate (18 ± 1 vs
18 ± 2 min−1, p = 0.38 and 18 ± 1 vs 18 ± 1 min−1, p = 0.84, respectively).
Conclusion
Changes in HR characteristics during deactivation of peripheral chemoreceptors but
not during the CFT and CPT are related with a decrease in respiratory rate. This highlights
the need of respiratory rate assessment when evaluating adaptations of cardiorespiratory
chemoreceptor control.
Keywords
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Article Info
Publication History
Published online: June 14, 2022
Accepted:
June 13,
2022
Received in revised form:
May 29,
2022
Received:
March 10,
2022
Footnotes
☆All authors take responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.
Identification
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