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Transcutaneous vagus nerve stimulation and the realm of its therapeutic hopes and physiologic enigmas

  • Max J. Hilz
    Correspondence
    Corresponding author at: University of Erlangen-Nuremberg, Schlossplatz 4, D-91054 Erlangen, Germany; Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Affiliations
    Department of Neurology, University of Erlangen-Nuremberg, Erlangen, Germany

    Icahn School of Medicine at Mount Sinai, New York, NY, USA
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  • Armin Bolz
    Affiliations
    tVNS Technologies GmbH, Ebrardstr. 31, 91054 Erlangen, Germany
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Published:September 27, 2022DOI:https://doi.org/10.1016/j.autneu.2022.103039

      Abstract

      Vagus nerve stimulation (VNS) is an established treatment option for patients with treatment resistant epilepsy and depression. However, the procedure is invasive and has side-effects. Transcutaneous vagus nerve stimulation (tVNS) is a non-invasive alternative. Particularly transcutaneous stimulation at the outer ear is gaining increasing interest. While the scope of therapeutic tVNS applications is expanding, there are still questions regarding the optimal stimulation parameters and site as well as the physiology and pathways of auricular tVNS. This Special Issue of Autonomic Neuroscience: Basic & Clinical provides an introduction and overview on basic aspects as well as special topics of tVNS.

      Keywords

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