Highlights
- •The wavelet phase coherence and synchronization index were used to quantify cerebral autoregulation in healthy volunteers.
- •Sympathetic nervous activity may drive vasomotion at 0.1 Hz in both systemic and cerebral circulation.
- •Increased synchronization between arterial blood pressure and cerebral blood flow velocity was found around the respiratory frequency.
- •Low synchronization was found in the 0.05-0.15 Hz frequency interval.
Abstract
Dynamic cerebral autoregulation (CA) characterizes the cerebral blood flow (CBF) response
to abrupt changes in arterial blood pressure (ABP). CA operates at frequencies below
0.15 Hz. ABP regulation and probably CA are modified by autonomic nervous activity.
We investigated the CBF response and CA dynamics to mild increase in sympathetic activity.
Twelve healthy volunteers underwent oscillatory lower body negative pressure (oLBNP),
which induced respiratory-related ABP oscillations at an average of 0.22 Hz. We recorded
blood velocity in the internal carotid artery (ICA) by Doppler ultrasound and ABP.
We quantified variability and peak wavelet power of ABP and ICA blood velocity by
wavelet analysis at low frequency (LF, 0.05–0.15 Hz) and Mayer waves (0.08–0.12 Hz),
respectively. CA was quantified by calculation of the wavelet synchronization gamma
index for the pair ABP–ICA blood velocity in the LF and Mayer wave band.
oLBNP increased ABP peak wavelet power at the Mayer wave frequency. At the Mayer wave,
ABP peak wavelet power increased by >70 % from rest to oLBNP (p < 0.05), while ICA blood flow velocity peak wavelet power was unchanged, and gamma
index increased (from 0.49 to 0.69, p < 0.05). At LF, variability in both ABP and ICA blood velocity and gamma index were
unchanged from rest to oLBNP.
Despite an increased gamma index at Mayer wave, ICA blood flow variability was unchanged
during increased ABP variability. The increased synchronization during oLBNP did not
cause less stable CBF or less active CA. Sympathetic activation seems to improve the
mechanisms of CA.
Keywords
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Article info
Publication history
Published online: December 22, 2022
Accepted:
December 19,
2022
Received in revised form:
December 12,
2022
Received:
September 1,
2021
Identification
Copyright
© 2022 Published by Elsevier B.V.
