Highlights
- •TRPV1 desensitization increased CBT and BAT temperature but did not change tail skin temperature and HR during rest;
- •Abdominal TRPV1 desensitization intensified the social stress-mediated CBT and BAT increases;
- •TRPV1 abolished the increase in tail skin temperature that occurs during and after social stress;
- •TRPV1 desensitization delayed the HR recovery after the exposure to social stress.
Abstract
Aims
In rats, stress-induced hyperthermia caused by social interaction depends on brown
adipose tissue (BAT) thermogenesis and peripheral vasoconstriction. However, the peripheral
mechanisms responsible for regulating the level of hyperthermia during social stress
are still unknown. The transient receptor potential vanilloid 1 (TRPV1) subfamily,
expressed in sensory and visceral neurons, can serve as a thermoreceptor. Here, we
tested the hypothesis that the abdominal TRPV1 is essential in regulating stress-induced
hyperthermia during social stress.
Main methods
Male Wistar rats received an intraperitoneal injection of Resiniferatoxin (RTX) -
an ultra-potent capsaicin analog, (i.e., to desensitize the TRPV1 channels) or vehicle.
Seven days later, we evaluated the effects of abdominal TRPV1 channels desensitization
on core body temperature (CBT), brown adipose tissue (BAT) temperature, tail skin
temperature, and heart rate (HR) of rats subjected to a social stress protocol.
Key findings
We found abdominal TRPV1 desensitization increased CBT and BAT temperature but did
not change tail skin temperature and HR during rest. However, under social stress,
we found that abdominal TRPV1 desensitization heightened the increase in CBT and BAT
caused by stress. Also, it abolished the increase in tail skin temperature that occurs
during and after social stress. TRPV1 desensitization also delayed the HR recovery
after the exposure to the social stress.
Significance
These results show that abdominal TRPV1 channels desensitization heightens stress-induced
hyperthermia, causing heat dissipation during and after social stress, enabling optimal
thermal control during social encounters.
Keywords
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Article info
Publication history
Published online: January 26, 2023
Accepted:
January 24,
2023
Received in revised form:
December 22,
2022
Received:
May 18,
2022
Identification
Copyright
© 2023 Elsevier B.V. All rights reserved.
